APERTUMNEURO
APERTUM
NEURO
Apertum / The short version01 — 04

Brain drug delivery. Rethought.

Same molecule.
New way in.

We’re developing a non-invasive way to help medicines cross the blood-brain barrier. Without redesigning the medicine.

How it works
A different approach to brain deliveryA therapeutic approaches a temporary opening in a barrier. This is a conceptual illustration, not an anatomical or clinical model.THERAPEUTICBRAINCONCEPTUAL / NOT TO SCALE
Investigational platform · Preclinical stageScroll to unfold ↓
The approach02 — 04

Change the access.
Not the therapy.

The blood-brain barrier restricts many medicines from reaching brain tissue. Apertum explores a temporary change in that barrier’s permeability.

  1. 01 / Prime

    Prepare the barrier.

    Non-invasive stimulation is designed to create a temporary delivery window.

  2. 02 / Infuse

    Use the existing molecule.

    The proposed workflow pairs priming with systemic administration of the therapeutic.

  3. 03 / Evaluate

    Measure brain exposure.

    Study whether more of the therapeutic reaches the central nervous system.

A delivery platform, not a drugWhere we are ↓
The stage03 — 04

Preclinical. Building toward translation.

Evidence first.
Then the next step.

The platform’s research spans rodent, porcine and non-human-primate models. Clinical safety and benefit still need to be established.

Explore the evidence
01 / Rodent

Reversibility

Investigating the temporary nature of the permeability change.

02 / Porcine

Permeability

Studying barrier access in a larger animal model.

03 / Non-human primate

Functional signal

AAV–ARSA proof-of-concept: measuring enzyme activity in brain tissue.

Animal findings do not establish efficacy in humans.
The opportunity04 — 04

For teams working on CNS therapeutics

Your molecule.
Our delivery question.

We’re looking to connect with biotech and pharma teams, research laboratories and investors exploring better access to the brain.

Small moleculesAntibodiesViral vectorsGenetic medicine
Let’s talk Explore Apertum →
Unlock the brain. Keep the molecule.Back to top ↑